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What happens when you activate GLP-1 and glucagon at the same time?
We need to talk about Survodutide—the GLP-1/glucagon dual agonist that’s shaking up the weight-loss world. This isn’t just another semaglutide lookalike. Survodutide brings a totally different approach by combining two powerful hormones—GLP-1 and glucagon—that usually don’t show up at the same time in the body.
In this video, I explain how GLP-1 helps regulate appetite, blood sugar, and digestion, while glucagon ramps up fat burning, increases metabolic rate, and keeps energy flowing during fasting. Survodutide forces these two into a unique metabolic partnership, delivering serious weight-loss results—nearly 19% average body weight reduction in clinical trials—and major benefits for liver health, including reduced inflammation and even reversal of liver damage in people with MASH.
But this isn’t a perfect drug. I go through the side effects you need to know about, like nausea, increased heart rate, and potential muscle loss if protein intake and strength training aren’t part of the plan.
This drug is still in Phase 3 trials, so we’re not quite at the finish line. But if you’re curious about what might be coming next in obesity treatment, Survodutide is one to watch.
Thanks for watching and always remember: small tweaks lead to massive peaks!
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📺 Watch These Next:
▪️ Watch This Before Taking Mounjaro
▪️ From Ozempic to Mounjaro
▪️ Muscle Loss with Ozempic, Wegovy & Mounjaro
▪️ Managing Nausea from Ozempic, Wegovy and Trulicity!
▪️ Ozempic: Stomach Paralysis Update
▪️ How to Switch from Ozempic (or Wegovy) to Mounjaro
▪️ Ozempic Paralyzed My Stomach
▪️ How to Inject Mounjaro: step-by-step tutorial
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🎯 Free Resources:
▪️ GLP-1/GIP Medication Info Sheet + 7-Day Food Journal
▪️ Total Daily Energy Expenditure (TDEE) Calculator – Find your optimal calorie intake
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🛒 Recommended Products for Your Weight-Loss Journey:
▪️ Managing Constipation
▪️ Managing Heartburn
▪️ Protein Bars & Supplements
▪️ Activity Trackers & Scales
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Live in Alberta? Come see me at my Pharmacist-led Obesity Clinic at Apothecare Pharmacy – http://apothecarerx.ca
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Dr. Dan
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