Video will be live on Monday, July 14 at 1:00 PM Central Time.
💎 OG Members Extended Version: How does Orforglipron compare to Rybelsus? And who should consider taking it?
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What the ACHIEVE-1 Trial Tells Us About the Future of Diabetes Care
I’m unpacking the latest data on Orforglipron, a once-daily oral GLP-1 receptor agonist that’s showing impressive results—lowering A1C by up to 1.5% and helping participants lose up to 15% of their body weight, without lifestyle intervention. We’ll look at the details from the ACHIEVE-1 Trial, including who was studied, how the trial was designed, and what the outcomes were across A1C, weight, cholesterol, and blood pressure.
If you’ve been navigating type 2 diabetes with diet and exercise alone, or have struggled with injections or food rules, this might be the most significant new option to know about.
For the OGs, I go deeper into who might be the best candidate for Orforglipron, who should hold off, and how it stacks up directly against Rybelsus in real-world use.
References
Rosenstock J, Hsia S, Nevarez Ruiz L, Eyde S, Cox D, Wu WS, Liu R, Li J, Fernández Landó L, Denning M, Ludwig L, Chen Y; ACHIEVE-1 Trial Investigators. Orforglipron, an Oral Small-Molecule GLP-1 Receptor Agonist, in Early Type 2 Diabetes. N Engl J Med. 2025 Jun 21. PMID: 40544435.
Thanks for watching and always remember: small tweaks lead to massive peaks!
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🎯 Free Resources:
▪️ GLP-1/GIP Medication Info Sheet + 7-Day Food Journal
▪️ Total Daily Energy Expenditure (TDEE) Calculator – Find your optimal calorie intake
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🛒 Recommended Products for Your Weight-Loss Journey:
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▪️ Activity Trackers & Scales
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Live in Alberta? Come see me at my Pharmacist-led Obesity Clinic at Apothecare Pharmacy – http://apothecarerx.ca
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Dr. Dan
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