Rybelsus: Oral Ozempic?

Have you heard of Oral Ozempic? It’s all over the news headlines as of late.

Have you heard of Rybelsus? Same same, but different?

A little while ago (okay, more like a year or two), I made a video comparing Ozempic to Rybelsus and talking about how it’s kind of the crappy form of Ozempic.

Is this still true?

Let’s get into it.

References:

▪️ Knop FK, Aroda VR, do Vale RD, Holst-Hansen T, Laursen PN, Rosenstock J, Rubino DM, Garvey WT; OASIS 1 Investigators. Oral semaglutide 50 mg taken once per day in adults with overweight or obesity (OASIS 1): a randomised, double-blind, placebo-controlled, phase 3 trial. Lancet. 2023 Jun 23:S0140-6736(23)01185-6. doi: 10.1016/S0140-6736(23)01185-6. Epub ahead of print. PMID: 37385278.

▪️ Wilding JPH, Batterham RL, Calanna S, Davies M, Van Gaal LF, Lingvay I, McGowan BM, Rosenstock J, Tran MTD, Wadden TA, Wharton S, Yokote K, Zeuthen N, Kushner RF; STEP 1 Study Group. Once-Weekly Semaglutide in Adults with Overweight or Obesity. N Engl J Med. 2021 Mar 18;384(11):989-1002. doi: 10.1056/NEJMoa2032183. Epub 2021 Feb 10. PMID: 33567185.

▪️ Rodbard HW, Dougherty T, Taddei-Allen P. Efficacy of oral semaglutide: overview of the PIONEER clinical trial program and implications for managed care. Am J Manag Care. 2020 Dec;26(16 Suppl):S335-S343. doi: 10.37765/ajmc.2020.88554. PMID: 33439582.

Dr. Dan

Follow me on social media for regular updates – @TheOfficialDrDan

Subscribe to my newsletter for a heads-up on all new content.

Sharing is caring! Here’s the social, email, and even text link – https://healthevolved.co/oral-ozempic

If you need some coaching support on your weight management journey, you can book a consultation with me to see if you’d be a good fit for our program. 

Questions or comments? Please send them my way on our Contact Us page!

Share:

More Posts

SURMOUNT-1 Sub-Study on Muscle Loss

Discover what the SURMOUNT-1 sub-study reveals about muscle loss on tirzepatide (Zepbound). Learn how much lean mass is typically lost during weight loss, what that means for your health, and the key strategies to protect your muscle while using weight-loss medications.

5 Ways to Boost Your Natural GLP-1

If you’ve heard claims about “natural Ozempic alternatives,” this is your reality check. I break down what the science actually says about the habits that can support appetite regulation, blood sugar control, and overall metabolic health. Whether you’re on GLP-1 meds like Ozempic or just looking to support your body naturally, here’s what actually works.

GLP-1s & Diabetic Retinopathy: Myth vs. Reality

GLP-1 medications like Ozempic and Wegovy have sparked concern about their impact on diabetic retinopathy. I break down what diabetic retinopathy is, how it develops, and the real risks of rapid blood sugar changes. Learn how to protect your vision while managing diabetes or obesity effectively.

Do GLP-1 Medications Increase Thyroid Cancer Risk?

A new study has raised concerns about GLP-1s like Ozempic, Wegovy, and Mounjaro—but is the fear justified? I break down the real findings, the role of early detection bias, and what it actually means for GLP-1 users. Get the facts, not the fear.

Send Us A Message

Try My New Calorie Calculator!

Calculate your daily calorie and protein targets to help you achieve your weight goals.

Try My New Calorie Calculator!

Calculate your daily calorie and protein targets to help you achieve your weight goals.