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Is one shot a month the future of weight loss meds?
I’m breaking down maridebart cafraglutide (aka “MariTide”), a once-monthly GLP-1 medication that could offer up to 20% body weight reduction—without the weekly injections or fridge full of pens.
I explain how MariTide flips the usual GLP-1 script by activating GLP-1 and blocking GIP—a gut hormone that, in obesity, may actually work against you. We’ll walk through what GIP does, why blocking it could help, and how this differs from other meds like Wegovy, Ozempic, or Zepbound.
Then I go over the Phase 2 trial results:
- 592 adults with and without type 2 diabetes
- 12–20% weight loss (depending on dose and adherence)
- Big drops in fat mass and A1C
- GI side effects that improved significantly with slow dose escalation
I also share what this all means in the real world—who MariTide might be best for, why monthly dosing isn’t always a slam dunk, and how it compares to other medications on the market.
References
Jastreboff AM, Ryan DH, Bays HE, Ebeling PR, Mackowski MG, Philipose N, Ross L, Liu Y, Burns CE, Abbasi SA, Pannacciulli N; MariTide Phase 2 Obesity Trial Investigators. Once-Monthly Maridebart Cafraglutide for the Treatment of Obesity – A Phase 2 Trial. N Engl J Med. 2025 Jun 23. doi: 10.1056/NEJMoa2504214. Epub ahead of print. PMID: 40549887.
Thanks for watching and always remember: small tweaks lead to massive peaks!
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📺 Watch These Next:
▪️ Watch This Before Taking Mounjaro
▪️ From Ozempic to Mounjaro
▪️ Muscle Loss with Ozempic, Wegovy & Mounjaro
▪️ Managing Nausea from Ozempic, Wegovy and Trulicity!
▪️ Ozempic: Stomach Paralysis Update
▪️ How to Switch from Ozempic (or Wegovy) to Mounjaro
▪️ Ozempic Paralyzed My Stomach
▪️ How to Inject Mounjaro: step-by-step tutorial
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🎯 Free Resources:
▪️ GLP-1/GIP Medication Info Sheet + 7-Day Food Journal
▪️ Total Daily Energy Expenditure (TDEE) Calculator – Find your optimal calorie intake
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🛒 Recommended Products for Your Weight-Loss Journey:
▪️ Managing Constipation
▪️ Managing Heartburn
▪️ Protein Bars & Supplements
▪️ Activity Trackers & Scales
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Live in Alberta? Come see me at my Pharmacist-led Obesity Clinic at Apothecare Pharmacy – http://apothecarerx.ca
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Dr. Dan
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https://healthevolved.co/maritide
If you need some coaching support on your weight management journey, you can book a consultation with me to see if you’d be a good fit for our program.
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