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Myth-Busting: Desensitization and Damage to GLP-1 Receptors
Have you ever heard someone say that GLP-1 medications like Wegovy, Ozempic, or Zepbound stop working over time—or worse, that they damage your GLP-1 receptors? Some even suggest cycling off these medications to “reset” your system. Let me set the record straight.
In this video, I’m busting myths about desensitization, damage, and downregulation of GLP-1 receptors. I’ll walk you through the science of how these medications actually work, why they don’t “wear out” your receptors, and what real-world studies like SELECT and STEP 5 tell us. (Spoiler: these meds keep doing their job even when weight loss slows down.)
We’ll talk about the realities of weight-loss plateaus, how your body’s natural metabolic adaptations come into play, and why cycling off these meds might make it harder to reach or maintain your goals. I’ll also share why managing expectations is so important and how to navigate the noise from influencers and misinformation online.
Thanks for watching and always remember: small tweaks lead to massive peaks!
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Watch my previous videos to learn how to fight obesity and about the best medicine for weight loss:
▪️ Watch This Before Taking Mounjaro
▪️ From Ozempic to Mounjaro
▪️ Muscle Loss with Ozempic, Wegovy & Mounjaro
▪️ Managing Nausea from Ozempic, Wegovy and Trulicity!
▪️ Ozempic: Stomach Paralysis Update
▪️ How to Switch from Ozempic (or Wegovy) to Mounjaro
▪️ Ozempic Paralyzed My Stomach
▪️ How to Inject Mounjaro: step-by-step tutorial
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Live in Alberta? Come see me at my Pharmacist-led Obesity Clinic at Apothecare Pharmacy – http://apothecarerx.ca
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Products I recommend to support your weight-loss journey:
▪️ Managing Constipation
▪️ Managing Diarrhea
▪️ Managing Heartburn
▪️ Internalized Weight Bias
▪️ Protein Bars
▪️ Scales and More
▪️ Supplements
▪️ Activity Trackers
▪️ My favorite Books
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Dr. Dan
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