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Which Weight Loss Medication Delivers More—CagriSema or Tirzepatide?

What if an injectable helped over half of users lose 20% of their body weight, with nearly a third dropping over 25%? 

That’s CagriSema—a combo of semaglutide and cagrilintide that tackles appetite from two angles. Semaglutide slows gastric emptying and reduces cravings, while cagrilintide mimics the body’s natural fullness signals.

I’m sharing results from the REDFINE-1 trial, a 68-week Phase 3 study with over 3,400 participants across 22 countries, comparing CagriSema to semaglutide alone, cagrilintide alone, and placebo—alongside lifestyle counseling. CagriSema users lost an average of over 20% body weight, with more than half achieving 20% or greater weight loss—results often seen with surgery, but without the risks.

Besides weight loss, CagriSema improved blood pressure and normalized blood sugar in most with prediabetes, showing important health benefits. Side effects like nausea were common but serious issues were rare. Compared to tirzepatide, CagriSema offers strong appetite suppression with similar weight loss, adding another powerful option for obesity treatment.

If you’ve hit a plateau on other meds or struggle with cravings, CagriSema could be a promising future choice. 

References:
Garvey WT, Blüher M, Osorto Contreras CK, Davies MJ, Winning Lehmann E, Pietiläinen KH, Rubino D, Sbraccia P, Wadden T, Zeuthen N, Wilding JPH; REDEFINE 1 Study Group. Coadministered Cagrilintide and Semaglutide in Adults with Overweight or Obesity. N Engl J Med. 2025 Jun 22. doi: 10.1056/NEJMoa2502081. Epub ahead of print. PMID: 40544433.

Thanks for watching and always remember: small tweaks lead to massive peaks!

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📺 Watch These Next:
▪️ Watch This Before Taking Mounjaro
▪️ From Ozempic to Mounjaro
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▪️ Managing Nausea from Ozempic, Wegovy and Trulicity!
▪️ Ozempic: Stomach Paralysis Update
▪️ How to Switch from Ozempic (or Wegovy) to Mounjaro
▪️ Ozempic Paralyzed My Stomach
▪️ How to Inject Mounjaro: step-by-step tutorial

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🎯 Free Resources:
▪️ GLP-1/GIP Medication Info Sheet + 7-Day Food Journal
▪️ Total Daily Energy Expenditure (TDEE) Calculator – Find your optimal calorie intake

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🛒 Recommended Products for Your Weight-Loss Journey:
▪️ Managing Constipation
▪️ Managing Heartburn
▪️ Protein Bars & Supplements
▪️ Activity Trackers & Scales

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Live in Alberta? Come see me at my Pharmacist-led Obesity Clinic at Apothecare Pharmacy – http://apothecarerx.ca 

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Dr. Dan

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