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Oral Wegovy Results Are In
What if the so-called “crappy cousin” of Ozempic—Rybelsus—wasn’t so disappointing after all? Oral Wegovy, the pill form of semaglutide, is showing results that rival injections when taken correctly.
In the OASIS-4 trial, a 25 mg daily dose led to an average 16.6% weight loss in 64 weeks. That’s impressive, but the routine is strict: one pill first thing in the morning, only with water, and then no food, meds, or even coffee for 30 minutes. Miss that step and absorption plummets.
Side effects like nausea and constipation were common, though less intense than at higher doses. For some, a daily pill could be a real alternative to injections—especially if needles are a barrier. For others, the once-weekly shot may still feel easier.
At the end of the day, oral Wegovy isn’t perfect, but it’s a legitimate new tool. For the right person, it could make the difference between starting treatment and never starting at all.
Thanks for watching and always remember: small tweaks lead to massive peaks!
References:
Wharton S, Lingvay I, Bogdanski P, Duque do Vale R, Jacob S, Karlsson T, Shaji C, Rubino D, Garvey WT; OASIS 4 Study Group. Oral Semaglutide at a Dose of 25 mg in Adults with Overweight or Obesity. N Engl J Med. 2025 Sep 18;393(11):1077-1087.
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📺 Watch These Next:
▪️ Watch This Before Taking Mounjaro
▪️ From Ozempic to Mounjaro
▪️ Muscle Loss with Ozempic, Wegovy & Mounjaro
▪️ Managing Nausea from Ozempic, Wegovy and Trulicity!
▪️ Ozempic: Stomach Paralysis Update
▪️ How to Switch from Ozempic (or Wegovy) to Mounjaro
▪️ Ozempic Paralyzed My Stomach
▪️ How to Inject Mounjaro: step-by-step tutorial
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🎯 Free Resources:
▪️ GLP-1/GIP Medication Info Sheet + 7-Day Food Journal
▪️ Total Daily Energy Expenditure (TDEE) Calculator – Find your optimal calorie intake
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🛒 Recommended Products for Your Weight-Loss Journey:
▪️ Managing Constipation
▪️ Managing Heartburn
▪️ Protein Bars & Supplements
▪️ Activity Trackers & Scales
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Live in Alberta? Come see me at my Pharmacist-led Obesity Clinic at Apothecare Pharmacy – http://apothecarerx.ca
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Dr. Dan
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