Have you heard of Oral Ozempic? It’s all over the news headlines as of late.

Have you heard of Rybelsus? Same same, but different?

A little while ago (okay, more like a year or two), I made a video comparing Ozempic to Rybelsus and talking about how it’s kind of the crappy form of Ozempic.

Is this still true?

Let’s get into it.

References:

▪️ Knop FK, Aroda VR, do Vale RD, Holst-Hansen T, Laursen PN, Rosenstock J, Rubino DM, Garvey WT; OASIS 1 Investigators. Oral semaglutide 50 mg taken once per day in adults with overweight or obesity (OASIS 1): a randomised, double-blind, placebo-controlled, phase 3 trial. Lancet. 2023 Jun 23:S0140-6736(23)01185-6. doi: 10.1016/S0140-6736(23)01185-6. Epub ahead of print. PMID: 37385278.

▪️ Wilding JPH, Batterham RL, Calanna S, Davies M, Van Gaal LF, Lingvay I, McGowan BM, Rosenstock J, Tran MTD, Wadden TA, Wharton S, Yokote K, Zeuthen N, Kushner RF; STEP 1 Study Group. Once-Weekly Semaglutide in Adults with Overweight or Obesity. N Engl J Med. 2021 Mar 18;384(11):989-1002. doi: 10.1056/NEJMoa2032183. Epub 2021 Feb 10. PMID: 33567185.

▪️ Rodbard HW, Dougherty T, Taddei-Allen P. Efficacy of oral semaglutide: overview of the PIONEER clinical trial program and implications for managed care. Am J Manag Care. 2020 Dec;26(16 Suppl):S335-S343. doi: 10.37765/ajmc.2020.88554. PMID: 33439582.

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Dr. Dan

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