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Today, we’re diving into why losing weight can be so challenging for people with type 2 diabetes. Despite fancy new medications like Zepbound, managing weight remains a tough battle for those with this condition. Interestingly, shedding pounds can actually help manage diabetes, but the disease itself makes weight loss harder. Let’s explore why this happens through the SURMOUNT-1 and SURMOUNT-2 trials.
In these studies, participants received either tirzepatide or a placebo over 72 weeks. Both groups aimed for a 500-calorie daily deficit and at least 150 minutes of activity per week. SURMOUNT-1 participants, who only had obesity, lost about 21% of their baseline weight. Meanwhile, SURMOUNT-2 participants, who had both obesity and type 2 diabetes, lost about 15%.
This 6% difference highlights how type 2 diabetes impacts weight loss. Even with similar interventions, those with diabetes struggled more. Factors like age, weight, and medications like metformin were considered but didn’t fully explain the discrepancy.
So, why does diabetes make it tougher to lose weight? One theory involves insulin resistance, which increases hunger signals. Another possibility is a reduced response to weight-loss medications due to fewer hormone receptors. Complications like neuropathy might also play a role.
In the end, managing diabetes and obesity is complex. Losing weight is still beneficial for managing diabetes, but it might be harder and slower. Remember, focus on overall health rather than just numbers on the scale.
Thanks for watching and I’ll catch you next week!
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Remember, small tweaks lead to massive peaks!
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Watch my previous videos to learn how to fight obesity and about the best medicine for weight loss:
▪️ Watch This Before Taking Mounjaro
▪️ From Ozempic to Mounjaro
▪️ Muscle Loss with Ozempic, Wegovy & Mounjaro
▪️ Managing Nausea from Ozempic, Wegovy and Trulicity!
▪️ Ozempic: Stomach Paralysis Update
▪️ How to Switch from Ozempic (or Wegovy) to Mounjaro
▪️ Ozempic Paralyzed My Stomach
▪️ How to Inject Mounjaro: step-by-step tutorial
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Live in Alberta? Come see me at my Pharmacist-led Obesity Clinic at Apothecare Pharmacy – http://apothecarerx.ca
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Products I recommend to support your weight-loss journey:
Managing Constipation
Managing Diarrhea
Managing Heartburn
Internalized Weight Bias
Protein Bars
Scales and More
Supplements
Activity Trackers
My favorite Books
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Dr. Dan
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