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Your Fat Tissue Is an Endocrine Organ Talking to Your Brain
Fat isn’t a passive storage tank; it’s an active endocrine organ that makes hormones like leptin, drives inflammation, and talks directly to the hunger circuits in your brain.
In this foundational video, I run through the pathophysiology of obesity as a disease, not a choice: leptin resistance, visceral fat and the liver connection, the thermostat vs. fuel gauge set point, and why your body defends weight loss far harder than weight gain. We also review what the 2011 New England Journal of Medicine study found a full year after weight loss — hunger up, fullness hormones down — and what the January 2025 Lancet Diabetes & Endocrinology Commission changed with preclinical vs. clinical obesity and diagnosis beyond BMI.
If you lost weight and watched it come back, let’s unpack why — it’s a signalling gap, not a willpower gap — and where modern obesity meds fit in.
Thanks for watching and always remember: small tweaks lead to massive peaks!
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Free Resources: GLP-1/GIP Medication Info Sheet + 7-Day Food Journal Total Daily Energy Expenditure (TDEE) Calculator – Find your optimal calorie intake
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Recommended Products for Your Weight-Loss Journey: Managing Constipation Managing Heartburn Protein Bars & Supplements Activity Trackers & Scales
Dr. Dan
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