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A recent study published in May 2024 unveiled a long-term outcome of Semaglutide, known as Wegovy or Ozempic. This builds on the SELECT trial, which showed Wegovy could reduce major cardiovascular events by 20% in individuals with obesity and no diabetes. Conducted by Ryan et al., the study followed participants for 208 weeks, or about four years.

The primary finding was not a new side effect but a continuation of Wegovy’s benefits. Participants experienced an average weight loss of about 10%, maintained over the entire four-year period. Initially, participants lost weight until around week 65, then sustained this weight reduction for the remainder of the study.

The results are impressive. The weight loss was not just temporary but sustained throughout the study’s duration. This stability contrasts with other long-term studies, such as those with Saxenda, where there is a tendency for weight regain over time. Wegovy’s ability to maintain weight loss over four years underscores its potential as a long-term weight management solution.

Regarding actual side effects, the study found no new or alarming issues. There were no new cases of cancers or other unusual conditions. About 17% of participants stopped taking Wegovy due to gastrointestinal side effects, aligning with other studies of GLP-1 medications. This finding supports the overall safety and effectiveness of Wegovy for long-term use.

In summary, this research highlights that the long-term “side effect” of Wegovy is a continued benefit: sustained weight loss over four years. This study reinforces the drug’s role in effective and durable weight management.

Thanks for watching and always remember: small tweaks lead to massive peaks! 

References: Ryan, D.H., Lingvay, I., Deanfield, J. et al. Long-term weight loss effects of semaglutide in obesity without diabetes in the SELECT trial. Nat Med (2024). https://doi.org/10.1038/s41591-024-02996-7

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Watch my previous videos to learn how to fight obesity and about the best medicine for weight loss: 
▪️ Watch This Before Taking Mounjaro  
▪️ From Ozempic to Mounjaro 
▪️ Muscle Loss with Ozempic, Wegovy & Mounjaro 
▪️ Managing Nausea from Ozempic, Wegovy and Trulicity!  
▪️ Ozempic: Stomach Paralysis Update  
▪️ How to Switch from Ozempic (or Wegovy) to Mounjaro  
▪️ Ozempic Paralyzed My Stomach 
▪️ How to Inject Mounjaro: step-by-step tutorial

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Live in Alberta? Come see me at my Pharmacist-led Obesity Clinic at Apothecare Pharmacy – http://apothecarerx.ca 

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Products I recommend to support your weight-loss journey: 
▪️ Managing Constipation 
▪️ Managing Diarrhea 
▪️ Managing Heartburn 
▪️ Internalized Weight Bias 
▪️ Protein Bars
▪️ Scales and More 
▪️ Supplements 
▪️ Activity Trackers  
▪️ My favorite Books 

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Dr. Dan

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